Kyle Walker and Gabriel Jesus have tested positive for coronavirus, Manchester City have confirmed.
Two members of staff also tested positive, the club said in a statement.
“All four personnel will now observe a period of self-isolation in accordance with Premier League and UK government protocol on quarantine,” said the Premier League side.
“Everyone at the club wishes our colleagues a speedy recovery over the Christmas period ahead of their return to work, training and competition.”
The England and Brazil internationals will now have to self-isolate instead of playing against Newcastle in Manchester City’s Boxing Day game.
They both featured in the side’s 4-1 win against Arsenal on Tuesday. The club did not say if the players or staff were suffering any symptoms.
Walker, 30, was forced to apologise after breaking COVID-19 lockdown rules with a visit to his home city of Sheffield in April.
He and Jesus, 23, are the latest in a string of football stars to contract coronavirus, which has also included Juventus and Liverpool stars Cristiano Ronaldo and Mo Salah.